Sarcoidosis: TB or not TB?
- 1Department of Rheumatology, Tel Aviv “Sourasky” Medical Centre, Israel
- 2Department of Radiology, Tel Aviv “Sourasky” Medical Centre
- 3Shmuel Harofe Geriatric Medical Centre and Tel Aviv University, Tel Aviv, Israel
Dr I Litinsky, Department of Rheumatology, Tel Aviv Sourasky Medical Centre, 6 Weizmann Street, Tel Aviv 64239, Israel
- Accepted 28 August 2001
A 37 year old man presented at another centre with a three week history of high grade fever, chills, and cervical lymphadenopathy. Routine laboratory tests as well as a purified protein derivative (PPD) test were within the normal ranges. Computed tomography of the chest and abdomen showed massive lymphadenopathy in the mediastinum and retroperitoneum. A cervical lymph node biopsy disclosed non-caseating granuloma negative for Mycobacterium tuberculosis by acid fast staining and culture. Sarcoidosis was diagnosed and the patient was treated with corticosteroids at a maximum dose of 60 mg/day for two months with complete resolution of the fever and lymphadenopathy.
Four months later, the patient developed right carpal tunnel syndrome, which was attributed to a lesion occupying space in the right radius; the tumour was removed and histology demonstrated non-caseating granuloma, interpreted as osseous sarcoidosis. A short course of corticosteroids was renewed and tapered off. He remained asymptomatic during the following six months when he developed oligoarthritis affecting the right ankle and wrist. Synovectomy of his right wrist showed non-caseating granuloma. Culture of the synovium was negative for Mycobacterium tuberculosis. Despite treatment with systemic and intra-articular steroids and addition of a three month course of weekly methotrexate, chronic and disabling monarthritis of the right ankle persisted, confining him to a wheelchair.
This time, a year after developing the oligoarthritis, the patient was admitted to our department. At presentation physical examination was normal except for his right ankle, which was extremely tender, swollen, and warm. A chest x ray examination and routine blood tests were normal except for increased acute phase reactants. The PPD test was 20 mm. Arthrocentesis of the right ankle produced 5 ml of white creamy fluid, which was positive for Mycobacterium tuberculosis by polymerase chain reaction (PCR) and culture. A magnetic resonance imaging (MRI) study of the joint disclosed by axial T1 fat suppressed gadolinium enhanced (fig 1) and sagittal STIR (fig 2) showed irregularly hyperaemic calcaneous bone with erosion on its posterior site (arrows), soft tissue abscess with enhancing walls (arrow heads), and large amounts of fluid.
Re-evaluation of the first lymph node biopsy ratified the diagnosis of non-caseating granuloma. However, PCR evaluation of the tissue was positive for Mycobacterium tuberculosis.
The patient was given multiagent 4 antituberculosis treatment for six months, and underwent arthrodesis of the right ankle, and his condition improved impressively.
We have presented a patient diagnosed with sarcoidosis. The diagnosis was based on repeated biopsies, confirming non-caseating granuloma, negative Mycobacterium cultures, negative PPD, and a complete response to corticosteroids. The patient developed chronic monarthritis of the right ankle, which turned out to be secondary to Mycobacterium tuberculosis infection.
Distinguishing between sarcoidosis and tuberculosis can be a challenge. The main manifestations of both diseases are in the lungs, in association with systemic symptoms such as fever, malaise, anorexia, and weight loss.1,2 Both diseases can affect the same organs; both can produce granuloma, which may be non-caseating in sarcoidosis as well as in tuberculosis.1,2 Musculoskeletal involvement is a well known manifestation of both diseases.3,4 Peripheral arthritis may be found in up to 5% of patients with tuberculosis5and up to 21% of patients with sarcoidosis.6,7
Our case raises a few intriguing questions of the relationships between sarcoidosis and tuberculosis: Was his disease tuberculosis masquerading as sarcoid from the very start of his medical puzzle? Or was it real sarcoid later complicated by tuberculosis in a patient who used corticosteroids?
The original diagnosis of sarcoidosis was supported by the clinical picture, the negative PPD test, the non-caseating granuloma, the absence of Mycobacterium tuberculosis, and his excellent response to corticosteroids. Does the positive retrospective PCR examination of the lymph node (biopsied two years previously) rule out the diagnosis of sarcoidosis? Several studies have shown the presence of Mycobacterium DNA in sarcoid granuloma, suggesting previous exposure to Mycobacterium, which might have induced a granulomatous reaction.8,9
The key to the diagnosis of tuberculosis is a high degree of awareness. The laboratory diagnosis is based on several methods such as direct microscopy, tissue culture, and PCR based nucleic acid amplification techniques. Although direct microscopy has low sensitivity (about 65%), tissue culture is a “gold standard” for diagnosis, with positive results for synovial fluid up to 80%. However, it requires four to six weeks before growth is detected.10 The principal advantage of PCR methods is that they provide a rapid diagnosis with extremely high sensitivity 97–100% and specificity of 90–100% for any form of tuberculosis infection (active, treated, or asymptomatic). On the other hand, the positive PCR test does not necessarily imply active tuberculosis, the specificity for the active form being only 70%.11–13
Undoubtedly, our patient developed active tuberculosis of the ankle. Corticosteroid treatment might have contributed to the reactivation of the tuberculosis,14 although the risk of corticosteroid treatment in patients with previous exposure to tuberculosis is probably lower than is generally believed.15,16
Finally, sarcoidosis and tuberculosis probably coexisted in this patient as has been previously shown in some other cases.17,18 Sarcoidosis and tuberculosis in the same patient do not exclude each other and the respective and mutual importance of both partners of this intriguing tandem should always be considered.
This case report taught us the longstanding, fascinating, yet mysterious, links between these two granulomatous diseases. It also showed us that in the process of differential diagnosis between sarcoid and tuberculosis the correct word between the two may not be just “or” but also “and”.
Reconsider the diagnosis if the response to treatment is not as expected.
Look for a chronic infection such as tuberculosis in patients with chronic monarthritis, despite an underlying disease which may explain the arthritis.
In cases of doubt—positive PCR and suspicious clinical suggestion of tuberculosis—an empirical antituberculosis treatment should be considered.