Ann Rheum Dis 61:1111-1112 doi:10.1136/ard.61.12.1111
  • Letter

Eosinophilic fasciitis with multiple myeloma: a new haematological association

  1. D Khanna1,
  2. A Verity2,
  3. J M Grossman1
  1. 1Division of Rheumatology, Department of Medicine, UCLA School of Medicine, Los Angeles, CA 90095-1670, USA
  2. 2Division of Neuropathology, Department of Neurology, UCLA School of Medicine, Los Angeles, CA 90095-1670, USA
  1. Correspondence to:
    Dr D Khanna, Division of Rheumatology, UCLA School of Medicine, 1000 Veteran Avenue, Room 32–59, Rehabilitation building, Los Angeles, CA 90095-1670, USA;
  • Accepted 8 May 2002

Eosinophilic fasciitis (EF) is characterised by skin induration, hypergammaglobulinaemia, and peripheral eosinophilia. There have been numerous reports of an association of EF with haematological disorders, including monoclonal gammopathy. To our knowledge, we describe the first reported case of an association of EF with multiple myeloma (MM).


A 48 year old white woman presented for evaluation of a 12 month history of progressive increasing skin thickness and tightening and recurrent falls. The patient was in her usual state of health until one year before admission when she noticed increased skin pigmentation with diffuse skin thickening, initially on the thighs but progressing to her abdomen and arms. She denied any Raynaud's phenomenon. On examination, the vital signs were normal. Examination was significant for skin thickening and induration of the thighs and arms. There was minimal sclerodactyly and no digital ulcers, scars or synovitis. No nailfold capillary abnormality was noticed. The oral aperture was mildly decreased with no evidence of telangiectasias. There were bilateral flexion contractures of the knees and the elbows. Results of chest, heart, and abdominal examinations were within …