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Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis
  1. Y Ersoy1,
  2. E Özerol2,
  3. Ö Baysal1,
  4. I Temel2,
  5. R S MacWalter3,
  6. Ü Meral1,
  7. Z E Altay1
  1. 1Department of Physical Medicine and Rehabilitation, Inonu University Faculty of Medicine, Turgut Ozal Medical Centre, 44069 Malatya, Turkey
  2. 2Department of Biochemistry, Inonu University Faculty of Medicine
  3. 3Department of Medicine, University of Dundee Medical School, Ninewells Hospital, Dundee, Scotland, UK
  1. Correspondence to:
    Professor Ersoy;
    dryuksel{at}hotmail.com

Abstract

Objective: To assess and compare serum nitrate and nitrite levels in patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA), and osteoarthritis (OA).

Methods: Thirty five patients with RA, 32 patients with AS, and 36 patients with OA were entered into this study. In addition, 30 healthy volunteers acted as a control group. Concentrations of nitrate and nitrite in serum were determined by direct and indirect Griess reactions. C reactive protein and erythrocyte sedimentation rate levels were determined as markers of systemic activity of disease (SAD) in RA and AS groups.

Results: Serum nitrate and nitrite levels were found to be higher in patients with AS and RA than in the OA group (p<0.01). In addition, serum nitrate and nitrite levels were higher in all three groups than in the control group (p<0.01). Moreover, serum nitrate and nitrite levels were higher in patients who had SAD than in those who had not in the RA and AS groups (p<0.01 and p<0.05, respectively), and there was a correlation between serum nitrate and nitrite concentrations and SAD variables in patients with RA (Spearman's rs=0.414, p<0.05 and rs=0.408, p<0.05, respectively) and AS (rs=0.421, p<0.05 and rs=0.412, p<0.05, respectively).

Conclusion: The findings suggest that nitrate and nitrite production is enhanced in patients with inflammatory arthritis compared with OA. In addition, serum nitrate and nitrite levels are enhanced in patients with RA, AS, and OA compared with healthy subjects. Furthermore, there is a correlation between the SAD variables and serum nitrate and nitrite levels in patients with RA and AS.

  • nitrate
  • nitrite
  • rheumatoid arthritis
  • ankylosing spondylitis
  • osteoarthritis
  • AS, ankylosing spondylitis
  • CRP, C reactive protein
  • ESR, erythrocyte sedimentation rate
  • NO, nitric oxide
  • NOS, nitric oxide synthase
  • OA, osteoarthritis
  • RA, rheumatoid arthritis
  • SAD, systemic activity of disease

https://doi.org/10.1136/ard.61.1.76

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    Footnotes

    • This study was presented as a poster at the 12th European Congress of Physical Medicine and Rehabilitation, 3–8 June 2000, Antalya, Turkey. YE, ÖB, ÜM, and ZEA designed the study; EÖ and IT performed the laboratory analyses, RSM advised and helped draft the paper, YE and RSM computed the data and annotated the graphics. YE is the guarantor of the paper. All authors assembled data and contributed to the interpretation and to drafting and revision of the paper.