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FRI0157 Anca antibodies in grave’s basedow disease
  1. M Gumà1,
  2. M Juan2,
  3. I Salinas3,
  4. E Casado1,
  5. V Ortiz-Santamaría1,
  6. A Olivé1
  1. 1Rheumatology
  2. 2Immunology, Hospital Universitari Germans Trias I Pujol, Badalona, Spain
  3. 3Endocrinology

Abstract

Background ANCA (anti-neutrophil cytoplasmic antibodies) are antibodies against specific proteins (proteinasa 3 and myeloperoxidase) and are present in the sera of patients having several underlying diseases).

Objectives To determine the frequency and specificity of ANCA in Grave’s disease.

Methods Thirty-five serum of patients with Grave’s Basedow disease were retrospectively examined. All patients were on treatment with anti-thyroid drugs at least for two months. ANCA antibodies were determined by indirect immunofluorescence. A ELISA test was performed to examine the presence of proteinasa 3 and myeolperoxidase (BL Diagnostica).

Results ANCA were positive in 60% of patients with Grave’s Basedow disease. Immunofluorescence patterns were as follow: 9 pANCA (26%), 7 xANCA (20%) and 5 cANCA (14%). ELISA was positive in just one case (myeloperoxidase).

Conclusion ANCA antibodies are positive in Grave’s Basedow disease. Anti-thyroid drugs may have a relationship with the presence of ANCA. Antigens are unknow.

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