Background ANCA (anti-neutrophil cytoplasmic antibodies) are antibodies against specific proteins (proteinasa 3 and myeloperoxidase) and are present in the sera of patients having several underlying diseases).
Objectives To determine the frequency and specificity of ANCA in Grave’s disease.
Methods Thirty-five serum of patients with Grave’s Basedow disease were retrospectively examined. All patients were on treatment with anti-thyroid drugs at least for two months. ANCA antibodies were determined by indirect immunofluorescence. A ELISA test was performed to examine the presence of proteinasa 3 and myeolperoxidase (BL Diagnostica).
Results ANCA were positive in 60% of patients with Grave’s Basedow disease. Immunofluorescence patterns were as follow: 9 pANCA (26%), 7 xANCA (20%) and 5 cANCA (14%). ELISA was positive in just one case (myeloperoxidase).
Conclusion ANCA antibodies are positive in Grave’s Basedow disease. Anti-thyroid drugs may have a relationship with the presence of ANCA. Antigens are unknow.
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