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SP0062 Fibromyalgia: evidence for a central nervous system disorder
  1. L Bradley
  1. Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA


This presentation reviews evidence from several studies in our laboratory regarding central factors associated with abnormal pain sensitivity in fibromyalgia (FM). We have found that, compared to healthy controls, clinic patients with FM and community residents who meet criteria for FM but have not consulted a physician (FM non-patients) display significantly lower pain thresholds in response to pressure stimulation and exhibit significantly higher cerebrospinal fluid (CSF) levels of substance P. In addition, during exposure to suprathreshold levels of pressure stimulation, controls and FM patients differ in changes in brain regional cerebral blood flow (rCBF). That is, controls show significant rCBF increases in the contralateral thalamus, somatosensory cortex, and the anterior cingulate cortex, whereas patients with FM show significant and bilateral increases in rCBF in these brain structures. Finally, patients with FM show greater cardiovascular responses to stress than controls. Moreover, stress produces greater increases in thermal pain unpleasantness ratings among FM patients compared to controls. Together, these findings indicate that FM patients show abnormal central processing of nociceptive stimuli that tends to be exacerbated by stress. We plan to determine whether the effects of stress on pain unpleasantness in FM (a) are associated with abnormal rCBF changes in the anterior cingulate cortex; and (2) may be mediated by abnormal cortisol release or cytokine production.


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  7. Pillemer SR, Bradley LA, Crofford LJ, et al. The neuroscience and endocrinology of fibromyalgia. Arthritis Rheum. 1997;40:1928–37

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