Objectives We used meloxicam at a doze of 15 mg a day for treating erythema nodosum (EN) of various aetiology in 47 patients (44 females and 3 males aged 15–68). Not depending on the EN aetiology, the main symptoms were fever (in 38 patients), joint pain (in 41 patients), foot and leg oedema (in 44 patients). The duration of EN syndrome before beginning meloxicam was from 2 weeks to 4 months. During this period all the patients underwent therapy by various NSAIDs (mainly diclofenac, ketoprofen, indometacin), 4 patients by steroids, antibiotics. In all the patients the previous therapy was either noneffective or little effective. Using meloxicam as a monotherapy on the 2-nd, 3-d day of taking the drug resulted in normalisation of temperature, disappearance of joint pain and oedema, quick decreasing of EN even in those patients who had no effect from steroids. In 4 patients the attempt of cancelling meloxicam lead to relapse of EN, fever and joint pain, which demanded resuming of meloxicam treatment. 4 patients had an allergy in the form of skin eruption and itch. That?s why meloxicam in those patients was cancelled in spite of a good effect. Meloxicam turned out to be ineffective in 2 patients. In 45 patients (95.7%) with pronounced EN, fever and oedema meloxicam showed great effectiveness.
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