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FRI0141 Prevalence of thyroid disease in systemic lupus erythematosus and primary sjÖgren syndrome
  1. M Alexandre,
  2. A Braña,
  3. A Barcelos,
  4. MJ Salvador,
  5. C Silva,
  6. L Inês,
  7. D Nour,
  8. P Reis,
  9. JA Pereira da Silva,
  10. A Malcata,
  11. A Porto
  1. Departement of Rheumatology, University Hospital of Coimbra, Coimbra, Portugal


Background Thyroid dysfunction (hypo and hypertiroidism) has been described among patients with connective tissue diseases, particularly in patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (PSS). Also a high prevalence of anti-thyroid antibodies (ATA) has been found in these patients.

Objectives To study:1) Thyroid function and morphology in a population of SLE and PSS patients; 2) To evaluate the prevalence of ATA in these patients; 3) To correlate clinical manifestations with laboratory data.

Methods We studied serum levels of thyroid hormones, TSH, anti-thyroglobulin and anti-microssomal antibodies in 70 consecutive patients (50 with SLE and 20 with PSS), followed in our department. We performed thyroid ultrasound in all patients. Patients were asked about signs and symptoms related to the manifestations of thyroid dysfunction.

Females (%)AgeYears of diseaseAbnormal thyroid morfology (%)Thyroid autoantibodies (%)Thyroid disfunction (%)Assymptomatic thyroid disease (%)
SLE 9640 ± 139 ± 838121856
PSS 9545 ± 127 ± 640252075
Abstract FRI0141 Table 1

Conclusion In this group of patients we found a high prevalence of thyroid morphology abnormalities and thyroid dysfunction. In both groups less than half of the patients with thyroid dysfunction presented related symptoms. These results suggest that all SLE and PSS patients should be routinely screened for thyroid disease even in the absence of clinical manifestations.

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