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FRI0137 Prolactin in systemic lupus erythematosus
  1. L Moszkorzova1,
  2. C Dostal1,
  3. J Marek2,
  4. Z Lacinova2,
  5. L Musilova1
  1. 11st Department, Institute of Rheumatology, Prague, Czech Republic
  2. 23rd Med. Department, 1st Med. Faculty Charles University, Prague, Czech Republic

Abstract

Background Prolactin (PRL) is an anterior pituitary hormone which is known to stimulate humoral and cell mediated immune responses, and may have a role in the pathogenesis of systemic lupus erythematosus (SLE).

Objectives To determine whether elevated serum prolactin associates the SLEDAI activity and/or specific organ involvement in SLE when recent reports have been till now discrepant.

Methods Basal serum PRL levels were determined in 55 consecutive SLE patients (pts) (49 females, 6 males) and in 41 healthy controls (31 females, 10 males) by RIA method. The estimated normal values of serum PRL were 200 mUI/l for males and 450 mUI/l for females.

Results The idiopathic hyperprolactinemia (hyper-PRL) was found in 7 SLE females (14,29%; 828,682 ± 391,410 mUI/l) and in 3 males (50,00%; 305,469 ± 65,751 mUI/l); and in one male in healthy controls (10,00%; 348,352 mUI/l) only. In remaining 42 SLE females and in 3 males PRL serum level was normal (365,783 ± 282,796 mUI/l; 142,854 ± 84,512 mUI/l). After 6 months repeatedly determined serum PRL in 2 females and 2 males with initial hyper-PRL, has shown normalisation in 1 female and 1 male. As to the proposed association between hyper-PRL and disease activity and specific organ involvement and presence of anti-ds-DNA there are some data on the Table 1.

Abstract FRI0137 Table 1

Conclusion There was significantly higher frequency of hyper-PRL in 55 SLE pts compared to 41 healthy controls (p < 0,001). The value of serum PRL has normalised in 2 pts with hyper-PRL from 4 pts with initial hyper-PRL without any specific treatment after 6 months by repeated estimation. We document a new idiopathic hyper-PRL in 1 patient with normal initial serum PRL. The association between hyper-PRL and activity and/or specific organ involvement and presence of anti-ds-DNA was not statistically significant due to low number of observations.

References

  1. Walker SE, et al. Effect of prolactin in stimulating disease activity in SLE. Proc NY Acad Sci 1998;840:762–72

  2. Neidhart M. Prolactin in autoimmune diseases. Proc Soc Exp Bio Med. 1998;217:408–79

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