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AB0074 Pulse methylprednisolone and cyclophosphamide therapy in three systemic lupus erythematosus patients with bronchiolitis obliterans organising pneumonia as the initial manifestation
  1. JC Tseng,
  2. HH Cheng,
  3. RJ Hu,
  4. LY Lu
  1. Allergy, Immunology and Rheumatology, Veterans General Hospital, Kaohsiung, Taiwan, R.O.C


Background Diverse pleuropulmonary manifestations are common in patients wtih systemic lupus erythematosus (SLE). Bronchiolitis obliterans organising pneumonia (BOOP) is a pathologic entity characterised by the formation of fibrous tissue plugs within terminal bronchioles and alveolar ducts. Although BOOP has been associated with several connnective tissue disorders, there are rare reports of BOOP in patients of SLE as the initial manifestation.

Objectives We described three SLE patients with open lung biopsy-proved BOOP as the initial manifestation which responsed well to pulse intravenous methylprednisolone and cyclophosphamide therapy. All three cases presented with fever, cough and dyspnea. Chest radiographs and CT scan of lung revealed bilateral pulmonary infiltrates. BOOP was confirmed by open lung biopsy. Pulmonary vasculitis was also demonstrated in lung histopathology in one case.

Results The pulmonary lesions and respiratory illnesses responsed well to monthly pulse intravenous methylprednisolone and cyclophosphamide therapy.

Abstract AB0074 Table 1

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