Article Text

PDF

FRI0091 Angiogenesis in systemic lupus erythematosus (sle) and primary antiphospholipid syndrome (paps)
  1. C Navarro1,
  2. L Candia-Zúñiga2,
  3. LH Silveira2,
  4. V Ruiz1,
  5. MC Amigo2
  1. 1Molecular Biology, Instituto Nacional de Enfermedades Respiratorias, Sección XVI, Mexico
  2. 2Rheumatoly Service, Instituto Nacional de Cardiología, Sección XVI, Mexico

Abstract

Background Angiogenesis is an essential process of the body´s physiology and plays a role in several diseases such as rheumatoid arthritis, neoplasias or atherosclerosis. Vascular endothelial growth factor (VEGF) and angiogenin (Ang) are factors that promote angiogenesis in vitro and in vivo. However, new vessels formation seems limited to tissues with some degree of inflammation or with hypoxia. SLE and PAPS are characterised by endothelial damage and the mechanisms of angiogenesis have not been explored in these diseases.

Objectives In this study we determine the possible role of VEGF and Ang in the pathogenesis of SLE and PAPS.

Methods We included 28 SLE patients, 10 PAPS patients and 24 matched controls. VEGF and Ang plasma levels were measured by ELISA.

Results The VEGF plasma levels were significantly increased in SLE patients compared with PAPS patients and controls, p < 0.01. The Ang levels were similar in the three groups. No correlation between VEGF levels and clinical manifestations was found.

Abstract FRI0091 Table 1

Conclusion The raised levels of VEGF in SLE might be related to the process of endothelial repair present in different organs of lupus patients.

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.