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THU0007 Association of human mhc class i and class ii genes with susceptibility to systemic lupus erythematosus in malays and chinese
  1. SS Yeap1,
  2. KF Kong2,
  3. YP Tee2,
  4. SK Chow1,
  5. ME Phipps2
  1. 1Department of Medicine
  2. 2Department of Allied Health Sciences, University of Malaya, Kuala Lumpur, Malaysia

Abstract

Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder. Its prevalence is higher in Chinese and Black populations compared to Caucasians. The prevalence of SLE in Malaysia is estimated to be 43/100,000 population.1

Objectives The objective of this study was to investigate the association between SLE with the human MHC Class I and Class II genes.

Methods A modified PCR-SSP Methodology, known as Phototyping2,3 was carried out to determine the HLA-A, -B, -DR and -DQ genes of the subjects. 50 Malays and 50 Chinese patients with SLE fulfilling the ACR criteria were recruited along with 50 Malays and Chinese age- and race-matched controls.

Results Statistical analysis showed that both the Malay and Chinese have similar results despite minor differences. HLA-A11 is associated with SLE in both races, whereas HLA-DR12 has been found to be statistically significant as protective antigen specificity. Compared to Malays, Chinese SLE patients have a higher frequency of DR2 compared to the controls. DRB1 was only seen in Malay SLE patients (OR 8.69 compared to controls). DRB1*02 and DQB1*05 was only seen in Chinese SLE patients (OR 2.41 compared to controls). Alleles negatively associated with SLE, possibly confering a protective effect are as follows: In both Malay and Chinese SLE patients, DRB1*12, DQB1*0301/4, in Malay SLE patients, DRB1*13, DRB3*0301, in Chinese SLE patients, DRB3*0201.

Conclusion These results differ from those obtained in other ethnic groups, i.e. suggesting a different disease pathogenesis.

References

  1. Wang F, et al. Lupus 1997;6:248–53

  2. Bunce M, et al. Tissue Antigens 1995;46:355–67

  3. Tee YP, et al. Asia Pacific J Mol Biol Biotech. 1999;7:29–37

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