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THU0186 The evaluation of the risk factors for generalised osteoporosis in patients with rheumatoid arthritis
  1. Ü Bingöl,
  2. L Altan,
  3. E Dinçsahin,
  4. M Yurtkuran
  1. Physical Therapy and Rehabilitation, Uludag University, Medical Faculty, Bursa, Turkey

Abstract

Background In patients with rheumatoid arthritis (RA), the frequency of generalised osteoporosis is increased. The factors related to the disease like duration, functional capacity, medical treatment (corticosteroid, nonsteroidal drugs, methotrexate) and disease activation (C-reactive protein, erythrocyte sedimentation rate) are present among the probable factors which increase the risk of generalised osteoporosis such as the general factors like sex, age and menapausal status.

Objectives The effects of the general risk factors and the risk factors related to the disease on the formation of osteoporosis were assessed statistically with the ordinal logistic regression test.

Methods The bone mass of 36 patients with RA (between the ages of 25 – 75 and duration of disease 0,25 – 43 years ? 32 female, 4 male) were evaluated with calcaneal ultrasound.

Results It was estimated that the risk of osteoporosis is increased 7.44 times in patients using nonsteroidal anti-inflammatory drugs (NSAID) compared with those who received no NSAID treatment. (P = 0.05, Odds Ratio = 7.44, 95% Confidence interval = 1 – 55.46)

Conclusion This data has shown us the importance of NSAID treatment in increasing the risk of generalised osteoporosis in RA patients.

References

  1. Laan RFJM, van Riel PLCM, van de Pute LBA. Bone mass in patients with rheumatoid arthritis. Ann Rheum Dis. 1992;51:826–32

  2. Gough AKS, Lilley J, Eyre S, Holder RL, Emery P. Generalized bone loss in patients with early rheumatoid arthritis. Lancet 1994;344:23–7

  3. Mellsh RWE, O’Sullivan MM, Garrahan NJ, Compston JE. Iliac crest trabeculer bone mass and structure in patients with non steroid treated rheumatoid arthritis. Ann Rheum Dis 1987;46:830–6

  4. Ewans WD, Ewans C. Long term follow up of spinal trabeculer bone mineral density in women with non-steroid treated rheumatoid arthritis. Ann Rheum Dis. 1994;53:149

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