Background It is well known that cytokines cause abnormal immunity affecting bone resorption in rheumatoid arthritis (RA). NTx (typeI collagen cross-linked N-telopeptides) is bone resorption marker, CARF (Anti-agalactosyl IgG antibodies) is a new rheumatoid factor which is able to detect all RF isotype, and allows early diagnosis of the onset of RA.
Objectives To find out the bone resorption in RA, we investigated the relation between NTx and CARF, inflammatory parameters CRP and ESR, Lansbury’s joint count which is the score for the affected joint.
Methods NTx and CARF were measured in 31 RA patients (male:1 case, female:30 cases). And CRP, ESR, Lansbury’s joint count was measured at the time, and examined about that relationship.
Results Significant positive correlations were observed between NTx and CARF (r2 = 0.211 p = 0.0093), and between NTx and joint count (r2 = 0.154 p = 0.0321), however, no significant correlations were observed between NTx and CRP or ESR.
Conclusion These results suggest that NTx has a potentiality as the joint destruction marker, reflecting not only general inflammation but also local inflammation such as arthritis.
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