Objectives To determine whether 1) the frequency of vitamin D receptor (VDR) polymorphisms in the rheumatoid arthritis (RA) patient group is different from that of the control group; and 2) there is a relationship between VDR genotypes vs the radiographic severity of RA and bone mineral density (BMD) in RA patients in Korea.
Methods The VDR genotype was determined by using polymerase chain reaction and by digestion with three restriction enzymes Taq I and Bsm I in elderly female controls (n = 78) and RA patients (n = 97). Hand X-rays were scored by Larsen’s method and femoral neck BMD was measured by dual energy X-ray absorptiometry in RA patients.
Results VDR genotypic distributions in Koreans were much different from those of Caucasians in both the control and RA group. In particular, “tt” and “BB” alleles were very rare, unlike the distribution in Caucasian population. No significant differences in VDR genotypic frequency were observed between the control group and the RA group. In addition, no significant relationship was found between the VDR genotypes and radiographic scores of RA, nor between the VDR genotypes and BMD in RA patients.
Conclusion The distribution of VDR polymorphisms in RA patients is not different from that of the controls. The VDR polymorphisms do not significantly correlate with the radiographic severity of RA, nor with BMD in Korean RA patients.
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