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AB0001 T-cell immunity in hla-b27+ and hla-b27- patients with reactive arthritis (rea) of different aetiology
  1. MB Dzhus,
  2. VV Chopyak
  1. Rheumatological Department, Lviv Medical University, Lviv, Ukraine

Abstract

Objectives Estimation of T-cell immunity pacularities in HLA B27+ and HLA B27- patients with reactive arthritis (ReA) of different aetiology.

Methods We observed 67 pts with ReA: male -62 pts., female 5 pts., mean age 27 ± 3, 2 yrs., men duration of illness 24 ± 6 months. In all patients triggering infections were detected: in 36 pts. high levels of chlamydia trachomatis IgG and IgM together with HSV I IgG and IgM were observed, in 16 pts.-serological activation of enterobacterial infection and in 10 pts. triggering agent was not found. Specific monoclonal antibodies were used to detect CD3+, CD4+, CD8+, CD16+, CD19+, CD22+ and presence of HLA-B27 antigen.

Results It was estimated that all patients with chlamidial infection were HLA-B27 positive. This pts had higher levels of CD4+ (p < 0,001), CD3+ (p < 0,01), CD22+ (p < 0,01), CD19+ (p < 0,001) and encreased level og IgG (p < 0,001) and CIC (p < 0,01) in comparison to HLA-B27 negative pts. Presence of HLA-B27 correlated with duration and activity of ReA.

Conclusion Chlamidial infection often associates with presence of HLA-B27 antigen. This pts. have more expressed changes in T-cell immunity that leads to the longer duration and severe activity of the disease.

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