Objectives This study was carried out to determine the serum levels of soluble intercellular adhesion molecule 1 (ICAM-1), nitric oxide and xanthine oxidase in patients with rheumatoid arthritis (RA) and to investigate the correlations between sICAM-1 and nitric oxide and xanthine oxidase.
Methods Serum samples were obtained from 30 patients with active RA and 20 healthy control subjects. sICAM-1, nitric oxide and xanthine oxidase levels were determined.
Results sICAM-1, nitric oxide and xanthine oxidase levels were significantly elevated in patients with RA (p < 0.001). We found a significant positive correlation between s ICAM-1 and nitric oxide (r = 0.426, p < 0.05). There was also a significant positive correlation between s ICAM-1 and xanthine oxidase (r = 518, p < 0.01).
Conclusion High levels of s ICAM 1 may be a a consequence of inflammation or tissue damage made by nitric oxide generated by xanthine oxidase.
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