Objectives Description of clinical findings and evolution in a cohort of patients with recent human parvovirus B19(PB19) infection and arthritis.
Methods 26 patients with arthritis and recent PB19 infection (high titers of anti-PB19 Ig M antibodies) were studied. Clinical (prodromal symptoms, arthritis pattern, extra-articular features and evolution) and analytical (blood count, Erythrocite sedimentation rate, C-reactive protein, antinuclear antibodies, anti-DNA antibodies, anti-cardiolipin antibodies, C3/C4 levels and urine abnormalities) data were collected. SLE(ACR,1982), RA(ARA,1987), and Fibromyalgia (Wolfe,1995) criteria were reviewed in each case.
Results Mean age of the 26 patients (23 female, 3 male) was 38.6 years. Three patients (11.5%) fulfilled > = 4 ACR criteria for SLE, and four patients (15.4%) had an SLE-like syndrome. Joint symptoms always manifested as an abrupt-onset arthritis; mainly as a polyarthritis (92.3%) with an additive (76.9%), symmetric (84.6%) pattern. Most of the patients became symptom-free in a period not longer than less than six months (< = 8 weeks: 76.9%; 8–24 weeks: 7.6%), and only 4 patients had a chronic course (SLE-like:2 patients; SLE: 1 patient; fibromyalgia: 1 patient).
Conclusion Most of the patients with a recent PB19 infection show a self-limited symmetric additive polyarthritis. Some of this patients may fulfil SLE, SLE-like or fibromyalgia criteria. This virus could act as a trigger in the etiopathogenesis of this diseases.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.