Background Connexion of obesity to osteoporosis (bone mineral density, BMD) and hyperostosis of the spine is not yet fully elucidated.
Objectives Their aim was to evaluate the connexion of osteoporosis (BMD of the spine and femur) and hyperostosis to obesity in a case-control study.
Methods The cases were 101 obese (BMI over 30 kg/m2) and controls were 101 non-obese (BMI 18,5–24,9 kg/m2) subjects matched by age and sex over the age of 50 years. There was not significant difference between cases and controls regarding the other main risk factors for osteoporosis (time spent from menopause, diabetes, hyperthyreoidism, alcohol and coffee intake, smoking, drugs causing osteoporosis). All probands in the case-control study were examined by radiographic investigation, vertebral morphometry, densitometry and by interviewer administered questionnaire. Radiographs were taken according to standardised protocol and hyperostosis was classified using Resnick criteria. Vertebral deformity was diagnosed with the McClosky-Kanis algorithm. Bone mineral density was measured by DEXA.
Results In the case-control study obesity was significantly associated with hyperostosis of the spine (p?0,05) with higher mean values of bone mineral density of the femoral neck (p?0,000), trochanter (p ?0,000), and lumbar spine p?0,014).
Conclusion According to their result obesity was associated with hyperostosis of the spine and with higher bone mineral density but not with fractures and osteoporosis in the past history.