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AB0174 Urinary excretion of type 1 collagen crosslinked n-telopeptides in rheumatoid arthritis: correlation with bone mineral density
  1. M Miyata,
  2. J Yahata,
  3. I Takizawa,
  4. Y Koike
  1. Orthpaedic Surgery, Morioka Red Cross Hospital, Morioka Iwate, Japan


Background A immunoassay for measuring urinary excretion of Type 1 collagen crosslinked N-Telopeptides (NTX) has been reported to be specific method for assessing bone resorption.

Objectives The aim of this study was to find out the value of urinary NTX as a marker of bone atrophy in RA.

Methods The study population consisted of 80 female patients with RA according to ARA criteria (1987), 42–74 years of age. We measured bone mineral density (BMD) in the radius and lumbar spine by dual energy X-ray absorptiometry in patients with RA. Using enzyme-linked immunoassays, the concentrations of urinary NTX was estimated in urine samples from RA patients.

A correlation between urinary NTx and BMD of RA patients was analysed.

Results In RA patients there were significant correlations between urinary NTX and BMD.

Conclusion This findings suggest that urinary NTX is the useful marker of bone atrophy in RA.

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