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AB0172 Turner syndrome and pure gonadal dysgenesis: a strong risk factor for osteopenia and osteoporosis
  1. C Benetti-Pinto,
  2. AJ Bedone,
  3. L Magna,
  4. JF Marques-Neto
  1. Internal Medicine, State University of Campinas (UNICAMP), Campinas, Brazil

Abstract

Background During the puberal period, the hormonal production is directly associated to bone mass, and related to the development of the peak of bone mass.

Objectives In order to evaluated the role of Primary Hypoestrogenism as a risk factor for osteopenia, 39 women, aged between 16 and 35 years old, with Pure Gonadal Dysgenesis and Turner Syndrome, were submitted to bone densitometry (DEXA) of lumbar spine and hip.

Methods Bone densitometry was performed using dual X-ray absorptiometry. T-score values (lumbar spine, femoral neck, Ward triangle and trochanter) were compared to treatment period and to the body mass index.

Results There were no difference between values of bone mineral density (BMD) in Pure Gonadal Dysgenesis and Turner Syndrome. But from all patients, compared to a normal control group, 90% showed a low BMD in lumbar spine (osteoporosis- 45% and osteopenia- 45%). The mean value of BMD in L2-L4 was 0,92 g/cm2.

Concerning to the femur BMD, 55% of the patients were affected (osteopenia in 50% and osteoporosis in 5%). The mean value of BMD was 0,83 g/cm2.

The density of lumbar spine was positively associated to treatment period (R = 0,57) and, in the femur, to the body mass index (R = 0,48).

Conclusion In conclusion, Primary Hypoestrogenism in the puberal period must be considered an important risk factor for osteopenia.

References

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  2. Kleerekoperm KS. Metabolic bone diseases sec IV primer on the metabolic diseases and disorders of mineral metabolism. 4th edn. Philadephia: Lippincott Williams & Wilkins, 1999

  3. Harper KD, Weber TJ. Secondary osteoporosis. Diagnostic considerations. Endocrinol Metabol Clin N Am.1988;27(2):325–47

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