Objectives To evaluate the efficacy and safety of combination analgesic tramadol/piroxicam for the treatment of low back pain.
Methods This 2- week study took place in two REHA-Centres in Croatia. Patients took medication as needed for the treatment of acute low back pain and/or osteoarthritis pain. They were given 20 mg of piroxicam in the morning and 50 mg of tramadol every 12 h for 15 days. Patients reported maximum pain relief (VAS scale 0 to 10) and rated overall efficacy (scale 1 = poor to 5 = excellent) at the final visit. Adverse events (AEs) were monitored throughout the study.
Results A total of 70 patients from two REHA-Centres provided data. We present the analysis of age, sex and profession. Most of our patients (61%) were employed. Our patients needed therapy for osteoarthritis pain (52%), low back pain (40%) and other (osteoporosis, RA, SA) 8%. After 15 days combination tramadol/piroxicam provided pain relief (range 2,5 ? 3,5). Overall efficacy of combination was rated 35% ?very good? or ?excellent? by 20%, ?good? by 35% and ?poor? by 10% only. There were no serious or unexpected AEs. The most common AEs were: nausea 20%, constipation 18%, headache 16%, dizziness 12% and somnolence 8%.
Conclusion This study demonstrated that the combination analgesic tramadol/piroxicam is effective and well tolerated in patients with low back pain and/or ostheoarthritis.
Statistics from Altmetric.com
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.