Article Text

PDF

SP0043 Epidemiology of cardiovascular complications in systemic lupus erythematosus
  1. M Petri
  1. Medicine, Division of Rheumatology, Johns Hopkins University, School of Medicine, Baltimore, USA

Abstract

Cardiovascular complications are increasingly recognised as a major cause of morbidity and mortality in SLE. The incidence of myocardial infarction is elevated 8 to 50-fold compared to age and gender matched controls. Traditional cardiovascular risk factors are increased in SLE, and are associated with both preclinical and clinical atherosclerosis. However, even after adjustment for traditional risk factors, a large difference in the frequency of cardiovascular disease exists between SLE patients and controls. In the general population, atherosclerosis is now recognised as a chronic inflammatory condition, with elevations of C-reactive protein and IL-6. TNF has a role in the pathogenesis of congestive heart failure. These and other inflammatory cytokines likely play a role in SLE. Furthermore, SLE patients are hypercoagulable secondary to antiphospholipid antibodies and other factors. Thus, the pathogenesis of cardiovascular complications in SLE is likely multifactorial, with both SLE and traditional risk factors playing a role.

Abstract SP0043 Table 1

Statistics from Altmetric.com

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.