Objectives To determine relation between serum levels of cartilage derived markers (cartilage oligomeric matrix protein ? COMP, human gp 39 – chondrex, YKL-40) and radiographic progression in knee osteoarthritis (OA) patients.
Methods A cohort of 202 patients with symptomatic knee OA was introduced into the study and followed-up over the period of 3 years. Serum levels of markers were measured at the baseline and at the end of the study. COMP was measured using monoclonal antibodies, developed in our institute. Chondrex was measured using chondrex-kit (Biometra, USA). Radiographic progression was defined as reduction of joint space width (JSW) > 0.5 mm over the 3 years follow-up. Baseline serum COMP and chondrex levels were compared in patients with and without radiographic progression and correlated with maximal JSW reduction (one knee) and a total of JSW reductions from both knees.
Results Totally 118 patients completed the 3 years follow-up; 22 of them showed JSW reduction at least in one knee joint. The levels of both markers in progressive and non-progressive groups are summarised in the Table 1.
Maximal JSW reduction (one knee) significantly correlated with entry and final COMP levels (ρ = 0.201, p < 0.05,ρ = 0.187, p < 0.05); JSW reduction from both knees correlated with final COMP level (ρ = 0.162, p < 0.05); the correlation with entry COMP level nearly reached the significance level (p = 0.07). Chondrex levels did not correlate with JSW reduction at all.
Conclusion COMP could represent biochemical predictor of radiographic progression in knee OA. The possible predictive role of chondrex in radiographic progression of knee OA was not proven in this study.
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