Background Three previously published studies aimed to relate rediographic disease progression in OA to baseline serum COMP levels (1–3). In two studies, the authors found no correlation between baseline serum COMP levels and subsequent progression of knee osteoarthritis (OA).1,2 In the study of hip OA, however, the authors found significant correlation between baseline serum COMP levels and yearly mean narrowing of joint space width.3
Objectives To evaluate serum COMP level measured at baseline with a new sandwich ELISA as a predictor of disease progression of knee OA.
Methods Patients with established OA (n = 54) represented placebo-taking group from finished and now opened 3-years long double-blind drug trial. Standing anthero-posterior radiographs of both knees were taken at the beginning and at the end of the study and used to measure joint space width at the medial compartment. COMP was quantified by newly developed sandwich ELISA with monoclonal antibodies 16-F12 and 17-C10.
Results The increased serum COMP level at baseline correlated with 3-years change of joint space width (expressed as the sum of joint space narrowing in both knees) (linear regression, r = 0.315, p < 0.05).
Conclusion We were able to relate serum COMP levels measured at baseline with the new assay to the radiographic progression of knee OA and extend the findings of Conrozier et al.3 from hip also to knee OA. At present, serum COMP level cannot be used to prognosticate OA course in individual patients due to high variability and overlap of values but it may help in sorting out groups of patients which are at risk of more aggresive development.
Sharif M, et al. Br J Rheumatol. 1995;34:306–10
Petersson IF, et al. Br J Rheumatol. 1998;37:46–50
Conrozier T, et al. Ann Rheum Dis. 1998;57:527–32
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