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OP0050 Immunogenetic aspects of erosive osteoarthritis of the hand
  1. R Ramonda,
  2. L Punzi,
  3. A Businaro,
  4. E Musacchio,
  5. F Schiavon,
  6. M Podswiadek,
  7. G Cardinale,
  8. S Todesco
  1. Divisions of Rheumatology and Clinical Medicine, Department of Medical and Surgical Sciences, University of Padova, Padova, Italy

Abstract

Background Erosive osteoarthritis of hand (EOA) is believed to be a subset of generalised OA characterised by frequent inflammatory episodes and an aggressive clinical course.

Objectives Since rare studies are available on the risk factors of EOA, we investigated its immunogenetic predisposition.

Methods In 47 patients with EOA (42 F, mean age 62.8 ± 8 years), HLA typing for A, B, C, DRB1 loci was performed. In the same patients we also evaluated the number of active joints (NAJ), the number of X-ray erosions (NEJ), the radiographic score (RS, Kallman), along with ESR and CRP.

Results The HLA antigens most frequently found in the 47 patients with EOA were A2 (16 = 34%), B5 (13 = 27.7%), Cw4 (13 = 27.7%), and DRB1011 (11 = 23.4%) and DRB103 (8 = 17%). Interestingly, the frequency of these two latter antigens were higher in EOA than in non-EOA patients (DRB1011 = 10%; DRB103 no found). NAJ (p < 0.01), RS (p < 0.001) and ESR (p < 0.01) were higher in EOA than in non-EOA. No differences were observed (ANOVA test) in NAJ, NEJ, RS, ESR and CRP, among the various HLA antigens found in EOA.

Conclusion EOA seems characterised by a high frequency, higher than in non-EOA, of some HLA antigens, in particular DRB103 and DRB1011, thus suggesting an immunogenetic predisposition in these patients. HLA antigens do not seem to be associated with the disease severity of EOA. However, more information may derive from an adequately long follow-up of these patients.

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