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AB0149 Studying of thew efficiency of the synvisk in osteoartrosis
  1. L Groppa,
  2. M Moshneaga
  1. Research Unit, Chisinau State University of Medicine and Pharmaceutics, Chisinau, Republic of Moldova

Abstract

Background At present for improvement of life quality in patients with osteoartrosis is necessary to solve some problems: precluding of development of degenerative process in cartilage of affected joint, relieving of pain and improvement of the function of the joint. For these aims we studied the efficiency of the chondroprotective drug Synvisk by Boenhringer Ingelheim in 25 patients with arthrosis of the knee in medium age of 61,2 ± 1,7 years, 16 women and 8 men, with duration of the disease 5,8 ± 0,9 years. Conform X-ray data the distribution of the patients by stages of the disease was as follow: I grade ? 20%, II grade ? 64%, and III grade ? 16%. In experimental group the drug was administered intraarticular by blind method in dose of 2,0 ml one time in a week, 3 injections for the course, which were repeated after 6 and 12 months. The control group was matched by gender, duration of disease and X-ray date; in this group was administrated placebo conforming same scheme.

Evaluation of the effectiveness and tolerability of compared drugs was carried out in evolution of clinical (pain, functional index by Lesquesne, volume of movement on affected joints), X-ray parameters and functional methods (ultrasonography, scintigraphy with Te99m.

In the basic group were mentioned decreasing of the pain intensity and improvement of the joint functions after single injection in one third of the patients, while in control groups similar cases were absent. After 3 courses of the treatment in the basic group the effects were obtained in 86,7% of the patients, including 33,3% very good effect, in 53,4% moderate effect and only in 13,3% the effects were absent. In control group there were no effect in 80% of the patients, and in 20% of the patients there were mentioned moderate effects; good effects were are not observed. Thus, a presented result suggests that administration of Synvisk lead to significant improvement of the life quality in the patients with arthrosis of the knee.

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