Background To evaluate the relationship between the presence of HLA-DRB1 genes and predisposition to AS in a demographically well-defined population.
Objectives 113 individuals with sporadic (non-familial) Ankylosing Spondylitis (AS) from six different cities and 747 bone marrow donors (BMD) as control group.
Methods All individuals were typed for HLA-B27 by either flow cytometry with monoclonal antibodies or PCR-SSP, as well as for HLA-DRB using the Dynal ELITM SSO HLA-DRB Test (Dynal AS, Oslo, Norway). The Inno-Lipa DRB key and DRB Decoder (Innogenetics NV Zwijndrecht, Belgium), which is based on PCR-SSO technology, was used for high-resolution HLA -DRB typing.
Results Table 1 shows the results.
Conclusion The incidence of the DRB1*01 antigen in the studied population is significantly higher in B27(+) healthy individuals (BMD) than in B27(+) AS patients. Also the incidence of this antigen is significantly higher in B27(-) AS patients than B27(-) healthy individuals. This could implicate that in the absence of B27, the DRB1*01 antigen could take part in the development of the disease.
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