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SAT0011 Association of phenotypic expression of ankylosing spondylitis (as) with the presence of hla-b60 antigen
  1. SN Tchepeleva,
  2. GV Loukina
  1. Department of Clinical Pharmacology, Institute of Rheumatology, Moscow, Russia

Abstract

Objectives To investigate the association of hip and eyes involvement with the presence of HLA-B60 antigen in AS patients.

Methods HLA-B60-typing was performed in 49 AS patients (all patients fulfilled the New York criteria for AS): 14 female and 35 male; mean age 38,8 years, mean disease duration 15,3 years. The diagnosis of anterior uveitis was verified by an ophthalmologist. Pelvic X-rays, ultrasonography of joints and densitometry were performed to estimate the hip involvement. Periarticular osteoporosis, joint space narrowing (<4 mm), osteophytes, cysts, erosive changes, aseptic necrosis of the femoral head, thickness of the synovial membrane and hip joint effusion were considered as the features of hip involvement.

Results 5 (10,2%) of 49 patients were B60-positive. 44 patients (89,8%) were B60-negative. 13 patients (26,5%) had anterior uveitis. All of them were B60-negative. The hip involvement was observed in 100% of B60-negative and in 80% of B60-positive AS patients.

Conclusion Our results consent to other authors? data about the less hip and eyes involvement in HLA-B60-positive AS patients. Further investigation is needed to confirm these results on the greater patient group.

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