Objectives To investigate the association of hip and eyes involvement with the presence of HLA-B60 antigen in AS patients.
Methods HLA-B60-typing was performed in 49 AS patients (all patients fulfilled the New York criteria for AS): 14 female and 35 male; mean age 38,8 years, mean disease duration 15,3 years. The diagnosis of anterior uveitis was verified by an ophthalmologist. Pelvic X-rays, ultrasonography of joints and densitometry were performed to estimate the hip involvement. Periarticular osteoporosis, joint space narrowing (<4 mm), osteophytes, cysts, erosive changes, aseptic necrosis of the femoral head, thickness of the synovial membrane and hip joint effusion were considered as the features of hip involvement.
Results 5 (10,2%) of 49 patients were B60-positive. 44 patients (89,8%) were B60-negative. 13 patients (26,5%) had anterior uveitis. All of them were B60-negative. The hip involvement was observed in 100% of B60-negative and in 80% of B60-positive AS patients.
Conclusion Our results consent to other authors? data about the less hip and eyes involvement in HLA-B60-positive AS patients. Further investigation is needed to confirm these results on the greater patient group.
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