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OP0069 Microchimerism and sjÖgren? s syndrome: a preliminary study on salivary glands
  1. F Carlucci1,
  2. A Stoppacciaro2,
  3. R Priori1,
  4. F Barone1,
  5. C Alessandri1,
  6. G Valesini1
  1. 1Divisione Di Reumatologia
  2. 2Istituto Di Anatomia Patologica, Università “La Sapienza”, Roma, Italy

Abstract

Background Recent researches suggested a role of microchimerism in the pathogenesis of systemic sclerosis and Graft Versus Host Disease.

Objectives Aim of the present study was to evaluate whether fetal microchimerism plays a role in the pathogenesis of Sjögren’s syndrome (SS).

Methods We looked for male microchimerism in minor salivary glands tissue from 6 women with SS and at least one male pregnancy or miscarriage. SS diagnosis was made according to EEC criteria. As control we used DNA from minor salivary biopsy of 3 women with SS and female pregnancies only, 1 woman with SS without previous pregnancies and 2 healthy women, one with a male pregnancy and one with a female pregnancy. We assayed by PCR for a specific Y chromosome sequence, SRY, and for the homologous gene of Amelogenin.

Results We didn’t find male DNA neither in the tissue from women with SS and male pregnancy nor in the controls.

Conclusion This preliminary study doesn’t support the hypothesis of a role of microchimerism in the pathogenesis of Sjögren’s syndrome, however further analysis should be performed to better clarify the hypothetical association between microchimerism and SS.

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