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FRI0219 Auto-antibodies in primary sjÖgren syndrome patients and histopathologic findings
  1. C Fernández-Carballido,
  2. JJ Alegre-Sancho,
  3. JA Román-Ivorra,
  4. A Villanueva,
  5. L Abad,
  6. B Pérez,
  7. S Fernández
  1. Rheumatology Unit, Hospital Universitario Dr. Peset, Valencia, Spain

Abstract

Objectives We have analysed the prevalence of antinuclear antibodies (ANA), Rheumatoid Factor (RF), anti-Ro/SSA and anti-La/SSB antibodies in patients with Primary Sjögren Syndrome (PSS) and different grades of minor salivary gland biopsies.

Methods 120 patients with PSS were included. All patients fulfilled > = 4 criteria and had a lip biopsy. We analysed the prevalence of ANA, RF, Anti-Ro/SSA and anti-La/SSB antibodies with regard to different grades of minor salivary gland biopsies. All biopsies were evaluated and classified according to Chisholm-Mason system by the same pathologist. Chi-square and Fisher tests were used; sensitivity and specificity for a positive biopsy (grades III and IV) were calculated.

Results No significative differences were detected between patients with grade II and III biopsies. Significative differences between grade III and IV were achieved for ANA (p = 0,02) and RF (p = 0,001).

Abstract FRI0219 Table 1

Conclusion In our PSS patients, auto-antibodies´ profile did not differ between patients with different grades of infiltration in lip biopsy.

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