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FRI0215 SjÖgren’s syndrome manifestations in primary biliary cirrhosis
  1. C Geli,
  2. J Enriquez,
  3. C Diaz,
  4. JM Llobet,
  5. M Moreno,
  6. C Diaz-Torne,
  7. A Rodriguez de la Serna,
  8. G Vazquez
  1. Rheumatology Unit, Hosptital de La Santa Creu I Sant Pau, Barcelona, Spain

Abstract

Objectives Study the Sjögren’s Syndrome (SS) manifestations in a sample of patients with Primary Biliary Cirrhosis.

Methods From October 1999 to May 2000 81 patients from the hepatology outpatient department were studied. We used the european criteria for the diagnostic of SS. Extraglandular clinical manifestations, analitical and inmunological study was evaluated using the unity protocol.

Results 90% were women. The mean age was 61 ± 11 y. Clinical evolution was of 6 years. Ocular dryness was present in 60(74%) and oral dryness in 60(76%). Schirmer and/or bengal´s rose were positive in 21(26%). The most common extraglandular manifestations were: Fibromialgy in 42(51%), Raynaud´s phenomenom in 21(26%), CREST´s syndrome in 13(16%), thyropathy in 21(26%), antythyroidal antibodies were positive in 19(24%)(Ten of them had hipothyroidism and two of them goitres), arthritis in 7(9%)(Two of them were erosive), inflammatory osteoarthritis in 5(6%), vasculitis in 3(4%), ANA >80 in 47(58%), Rheumatoid factor in 27(33%), SS-A/Ro antibodies in 14(17%) and SS-B/La in 8(10%). 9 CREST´s patients were positive for anticentromere antibodies. 41(50%) had 4 or more SS European criteria. A minor salival gland biopsy was realised in 53 patients. 39 of them were positive (73%). 41 of the biosed patients had 3 or more criteria. 31 of this 41 patients has a positive biopsy (75%). The other 12 patients had 2 or less criteria, just 5 of them had a positive biopsy (41%).

Conclusion There is a high prevalence of SS (50%) in patients with CBP. Keratoconjuctivitis sicca´s prevalence is 66%. Subjective involvement of oral and ocular dryness are 74% and 76% respectively. Fibromialgy is the rheumatological clinic more frequent, appearing in more than 50% of the patients.

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