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FRI0212 Correlation between histopathological findings, sero-immunological profile and markers of disease activity in sicca syndrome
  1. M Benucci,
  2. A Mannoni,
  3. F Li Gobbi,
  4. U Serni
  1. Rheumatology, I. O. T. ASL 10, Florence, Italy


Background We evaluated sero-immunological parameters and markers of disease activity in ninety-two patients all female who underwent lip biopsy for histological assessment of sicca syndrome, according new preliminary criteria proposed for classification of Sjogren Syndrome (S. S).

Objectives The aim of our study was to compare the histopathological score index according to Chisolm and Mason classification with twenty-two parameters of disease activity.

Methods We have classified thirty-seven patients (group A) with focus score I-II with probable S. S (positivity of 3/6 item) and fifty-five patients (group B) with focus score III-IV with defined S. S (positivity of 4/6 item). The mean age of two group was: group A 60 ± 11 years, group B 64 ± 9.8 years. The statistical comparison between the two group was performed with T-Student for 20 parameters and chi-square method for ANA and SSA/SSB positivity.

Results The comparison between the two groups show statistically significant differences for sero-immunological parameters such as gamma globulin (p < 0.01), SSA/SSB (p < 0.001). Moreover the group B shows higher levels of ESR (p < 0.005), fibrinogen (p < 0.02) and alpha1-antitrypsin (p < 0.005).

Conclusion This data show the important role of lip biopsy in the diagnosis of S:S and suggest the possible correlation between high histopathologic focus score and immunological markers of disease activity.


  1. Vitali C, et al. Arthritis Rheum. 1992;36:340–8

  2. Chisolm D, Mason D. J Clin Pathol. 1970;23: 690

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