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FRI0194 Central nervous system involvement in patients with systemic sclerosis: electroencephalographic study
  1. PJ Kotyla,
  2. B Sliwinska-Kotyla,
  3. EJ Kucharz,
  4. L Brzezinska-Wcislo
  1. Department of Internal Medicine and Rheumatology, Medical University of Silesia, Katowice, Poland


Background Central nervous system is rare affected in patients with systemic sclerosis. Subtle, very often non-specific symptoms and signs of the brain involvement in the patients were reported.

Objectives The present study was designed to detect and correlate electroencephalographic changes and to correlate them with the other neuro-psychiatric findings in patients with SSc.

Methods The study was performed in 12 SSc patients (11 women and 1 man). A routine 16-leads electroencephalograpic records were performed in the patients in morning hours after at least 8 h night rest. The patients underwent the following procedures during EEG examination: hyperpnea, intermittent photic stimulation (stroboscope light at 10 min at 10 to 30 Hz) EEG alteration were classified on the base of following criteria: generalised slow activity (4–6 Hz), and presence of sharp waves, theta (4–6Hz) delta (2–3 Hz). Focal alterations which fulfil the mentioned criteria were detected wit the special attention. In addition every patient underwent The routine neurologic examination was performed in every patients.

Results We recorded alpha rhythm of 9–11 Hz frequency and 20–100 uV amplitude as a basic rhythm in every patients. Nine patients showed no EEG abnormalities. In 5 patients we observed, especially in temporal regions presence of sharp waves induced mainly by hyperpnea. This group of patients presented symptoms of CNS involvement – mainly headaches, parasthesis, ataxia and some psychiatric abnormalities.

Conclusion In the course of SSc even subtle, non-specific symptoms may herald CNS involvement. EEG seems to be valuable method which confirm brain involvement in patients with SSc, presenting neurological and psychiatric abnormalities.

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