You are here

Article Text

Article menu
Download PDFPDF
Extended report
Immunohistological study of entheses in spondyloarthropathies: comparison in rheumatoid arthritis and osteoarthritis
  1. L Lalouxa,
  2. M-C Voisinb,
  3. J Allainc,
  4. N Martinb,
  5. L Kerboulld,
  6. X Chevaliera,
  7. P Claudepierrea
  1. aDepartment of Rheumatology, Hôpital Henri Mondor, Créteil, France, bDepartment of Pathology, Hôpital Henri Mondor, cDepartment of Orthopaedic Surgery, Hôpital Henri Mondor, dDepartment of Orthopaedic Surgery, Hôpital Cochin, Paris, France
  1. Dr P Claudepierre, Service de Rhumatologie, Hôpital Henri Mondor, 51 Avenue du Maréchal de Lattre de Tassigny, 94010 Créteil Cédex, Francepascal.claudepierre{at}hmn.ap-hop-paris.fr

Abstract

OBJECTIVE To determine which inflammatory cell types are present in entheses from patients with spondyloarthropathy (SpA) compared with patients with rheumatoid arthritis (RA) or osteoarthritis (OA).

METHODS Enthesis specimens were obtained during orthopaedic procedures in eight patients with SpA, four with RA, and three with OA. After decalcification, the lymphocyte subsets (CD3, CD4, CD8, CD20) in the bone marrow component of each enthesis were measured by an immunohistochemical technique.

RESULTS Oedema and an inflammatory infiltrate were present in all the SpA specimens, being clearly predominant in the bone marrow component of the entheses. The density of all cell types in the bone marrow was significantly higher in the SpA group than in the two other groups. The cell type CD3+ showed the greatest difference between the SpA and RA groups, being increased fivefold in the SpA group. Within the SpA group, CD3+ cells were considerably more numerous than CD20+ cells—a difference from the RA group—and the predominant T cells were CD8+.

CONCLUSION Persistent oedema with an inflammatory infiltrate composed predominantly of CD8+ cells was noted in the entheses of patients with SpA, being predominant in the bone marrow. These results suggest that CD8+ cells may have a key role in local inflammation in SpAs.

  • spondyloarthropathy
  • ankylosing spondylitis
  • entheses
  • lymphocytes

https://doi.org/10.1136/ard.60.4.316

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text