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The HLA-B*2709 subtype in a patient with undifferentiated spondarthritis
  1. IGNAZIO OLIVIERI,
  2. ANGELA PADULA,
  3. GIOVANNI CIANCIO
  1. LEDA MORO,
  2. ELISABETTA DURANTE
  1. CARLO GAUDIANO,
  2. SANTA MASCIANDARO
  1. SARAH POZZI,
  2. G B FERRARA
  1. Rheumatic Disease Unit
  2. of the S Carlo Hospital
  3. Potenza, Italy
  4. Tissue Typing Laboratory of the
  5. Blood Bank of “Ca” Foncello” Hospital
  6. Treviso, Italy
  7. HLA Typing Service of Matera Hospital
  8. Matera, Italy
  9. National Cancer Institute of the
  10. Advanced Biotechnology Centre
  11. Genova, Italy
  1. Dr Ignazio Olivieri, Servizio di Reumatologia, Ospedale S Carlo, Contrada Macchia, Romana, 85100 Potenza, Italy Email: ignazioolivieri{at}tiscalinet.it

https://doi.org/10.1136/ard.59.8.654a

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    In 1998, in this journal, we reported the cases of two B27 positive patients with undifferentiated spondyloarthropathy (uSpA) and showing dactylitis also affecting the synovial sheaths in the palm of the hand.1 Neither patient had axial disease but showed peripheral manifestations of spondyloarthropathy (SpA), such as peripheral arthritis, peripheral enthesitis, and dactylitis.

    Recently, one of our two patients (No 2) was subtyped and found to be B*2709 positive. As far as we know this subtype has never been found in patients with SpA.

    DNA typing of HLA class I alleles was performed using a DNA sample prepared from peripheral blood lymphocytes by the salting out procedure.2 The class 1 ABC SSP UNITRAY low resolution kit (Pel-Freez) was used. The primer sets amplify all alleles described by the International Nomenclature Committee of WHO in 19953and in …

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