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Ann Rheum Dis 2000;59:920-923 doi:10.1136/ard.59.11.920
  • Concise report

Splenectomy for refractory Evans' syndrome associated with antiphospholipid antibodies: report of two cases

  1. Josep Fonta,
  2. Sònia Jiméneza,
  3. Ricard Cerveraa,
  4. Mario García-Carrascob,
  5. Manuel Ramos-Casalsa,
  6. Jaume Campdelacreua,
  7. Miguel Ingelmoa
  1. aSystemic Autoimmune Diseases Unit, Department of Medicine, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain, bImmunology Department, Benémerita University School of Medicine, Puebla, México
  1. Dr Josep Font, Unitat de Malalties Autoimmunes Sistèmiques, Hospital Clínic, C/Villarroel, 170, 08036-Barcelona, Spain Email:font{at}medicina.ub.es
  • Accepted 27 March 2000

Abstract

The main haematological manifestations seen in patients with antiphospholipid antibodies (aPL) are thrombocytopenia, usually mild, and haemolytic anaemia with a positive Coombs test. Owing to the shared characteristics with idiopathic thrombocytopenic purpura, similar rules are followed in the treatment of these cytopenias. Two patients with severe aPL associated cytopenias, who required splenectomy after being refractory to steroids, immunosuppressive agents, and other treatments (intravenous gammaglobulin, danazol), are described, and previously reported cases are reviewed.

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