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Factors associated with fatigue in patients with systemic lupus erythematosus
  1. Ian N Bruce,
  2. Vincent C Mak,
  3. David C Hallett,
  4. Dafna D Gladman,
  5. Murray B Urowitz
  1. Centre for Prognosis Studies in The Rheumatic Diseases, University of Toronto Lupus Clinic, The Toronto Hospital, Toronto, Ontario, Canada
  1. Dr D D Gladman, Centre for Prognosis Studies in The Rheumatic Diseases, The Toronto Hospital, Western Division, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8.

Abstract

OBJECTIVE To examine the relation between fatigue, disease activity, damage, and quality of life measures in patients with systemic lupus erythematosus (SLE).

METHODS Consecutive patients attending the University of Toronto Lupus Clinic were studied. Disease activity was assessed using the SLEDAI and SLAM-R and damage using the SLICC/ACR Damage index. Fatigue was measured by the Fatigue Severity Score (FSS) and health status by the SF-36 questionnaire. In all cases a tender point count was also performed.

RESULTS 81 patients were studied. Their mean (SD) age and disease duration were 43 (12.5) years and 12.7 (8.0) years respectively. The FSS did not correlate with the SLEDAI nor with the SLAM-R. There was no correlation with the SLICC damage index. Fatigue severity correlated with the tender point count (SCC r=0.46, p<0.001), and negatively with all domains of the SF36 (r values −0.50 to −0.82). Disease activity and damage accounted for only 4.8% and 4% respectively of the variance in fatigue severity reported by patients.

CONCLUSION In an outpatient population of SLE patients, fatigue severity correlates with poor health status and a higher tender point count. In patients with SLE, factors associated with quality of life and fibromyalgia seem to have a greater influence on the severity of reported fatigue than does the level of current disease activity.

  • systemic lupus erythematosus
  • fatigue
  • disease activity
  • health status

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Fatigue is a very common symptom in systemic lupus erythematosus (SLE) and is described in over 50% of patients at some time during their illness.1 2 The cause of fatigue seems to be multifactorial although it is often interpreted as reflecting active disease. As such, it is included in several indices of disease activity.3 However, other conditions associated with fatigue also occur frequently in SLE including fibromyalgia, which has been reported in up to 22% of patients.4 5

In a previous study,6 we found that disease activity as assessed by the SLEDAI did not correlate with patients’ reporting of fatigue. This study suggested that fatigue was more closely associated with quality of life (QOL) (measured by the Medical Outcome Survey (MOS) SF-20), depression, and fibromyalgia. The potential contribution of accumulated organ damage to fatigue was not assessed.

The purpose of this study was to further examine which dimensions of disease in SLE are most closely associated with fatigue. We studied the relation of fatigue with disease activity using two indices, one that includes (SLAM-R)3 and one that excludes (SLEDAI)7 fatigue. We also assessed the relation of fatigue with overall damage, tender point count, and health related QOL, using the MOS SF-36, which is the accepted QOL measure for studies of SLE.8

Methods

PATIENT SELECTION

Consecutive patients attending the University of Toronto Lupus Clinic between March and May 1997 were included. All patients fulfilled ACR criteria for the Classficiation of SLE.9

CLINICAL EVALUATION

Patients with SLE are followed up prospectively at the University of Toronto Lupus Clinic. Our standard protocol includes all features of active disease and damage encountered by patients with SLE. It also includes a question on fatigue, as well as the assessment of fibromyalgia and a fibromyalgia tender point count at each visit. The SLEDAI7 is then calculated from the information collected on the protocol, and every 12 months the SLICC/ACR damage index is completed.10 For patients who had not had a SLICC/ACR damage index within six months of the current visit, it was completed again for the current visit. All patients are assessed by the directors of the clinic (Dr M B Urowitz or Dr D D Gladman) or by a clinical fellow trained by them.

ADDITIONAL ASSESSMENTS OF ACTIVITY, QUALITY OF LIFE, AND FATIGUE

During the patient’s visit in this time period, the following additional measures were completed:

The SLAM-R was completed for each patient. The SLAM includes a severity measure for some of the items, as well as some items, including fatigue, arthralgia and myalgia,which are not part of SLEDAI. This information was included in the standard assessment such that the SLAM could be completed as well. The clinical fellows involved in the study (INB and VCM) were instructed in the guidelines for use of this instrument, including the rules regarding attribution.

The patients also completed the following instruments:

(1) Fatigue Severity Score (FSS), this is a validated nine point questionnaire that assesses the effect of fatigue on daily activities.11 Each item is scored on a scale from 0–10, as modified from the original 1–7 scale by Gladmanet al 12 with an average overall score (0–10) being computed; a higher score denotes more severe fatigue.

(2) The Medical Outcomes Study 36-item short form health survey (SF-36). This is an extensively used measure of health related QOL.13 The questionnaire covers eight domains of health status—that is, physical function, role physical, role emotional, social functioning, bodily pain, mental health, vitality, and general health. Scores range from 0–100 in each domain with a higher score reflecting better performance.

Patients completed the SF-36 and FSS independent of their visit with the physician. The questionnnaires were returned to the research assistant and entered on computer. The physicians were blinded to the results of the patient derived questionnaires.

STATISTICAL ANALYSIS

Statistical analysis was performed using the SAS for PC package. The mean (SD) for each variable were calculated. Correlation analyses were calculated using Spearman’s coefficient of correlation. Ninety five per cent confidence intervals (95% CI) and p values are reported with p<0.05 being accepted as statistically significant.

Results

Eighty one patients were studied, 76 women and five men. The mean (SD) age and the mean (SD) disease duration at study were 43.4 (12.5) years and 12.7 (8.0) years respectively. Fifty eight (72%) were white, seven (9%) were black, and 16 (19%) were other races. Twenty four (30%) had a university education, 28 (35%) had college education, 25 (31%) completed high school, and four (5%) had elementary or less education. The 81 patients had complete information for the SLEDAI, SLAM-R, SLICC, FSS, and tender point scores. The SF-36 was completed in 51 patients. There were no differences with regard to patient characteristics, disease activity, damage, fatigue severity or tender point score between the 51 with complete information and the 30 who did not complete the SF-36 (data not shown).

The mean SLEDAI and SLAM-R scores at study were low (table 1). The level of fatigue reported was high; mean (SD) 6.08 (2.7). A previous study of healthy adults10 reported a mean score of 2.3 (0.7). Table 1 also displays the scores for each domain of the SF-36 in SLE patients that were lower than those reported for healthy US women.12 There was a good correlation between the SLEDAI and SLAM-R scores (r=0.44 (0.22, 0.58), p<0.001). There was no correlation between the SLEDAI and SLICC damage index (r=0.03 (−0.18, 0.25) and a poor correlation between the SLAM-R and the SLICC (r=0.27 (0.06, 0.47), p=0.01).

Table 1

Demographic details for each scale of activity, damage, fatigue and quality of life assessed in the patient population. The normal data for each domain in the SF-36 for the US population are displayed for comparative purposes

The fatigue severity score had a poor correlation with disease activity by both indices: SLAM-R (r=0.26, (0.04, 0.45) p=0.02), SLEDAI (r=0.22 (−0.01, 0.41), p=0.05), SLAM-R with fatigue score removed (r=0.11 (−0.12, 0.32), p=NS). There was also no relation between the FSS and SLICC (r=0.20 (−0.02, 0.40), p=0.07). The FSS correlated well with the tender point count (r=0.46, (0.27, 0.62) p<0.001). With regard to QOL, there were strong negative correlations between the FSS and all domains of the SF-36 with correlation coefficients ranging from −0.50 to −0.82 (table 2). The negative correlations reflect the fact that a high FSS reflects more fatigue, whereas a high SF-36 reflects better quality of life. The variance in fatigue accounted for by the SLEDAI and SLICC were 4.8% and 4.0% respectively. In contrast, the dimensions of the SF-36 accounted for 25–67% of the variance in the FSS.

Table 2

Correlation between the Fatigue Severity Scale (FSS) and health status in the eight domains of the SF-36 (r values and 95% CI)

Discussion

We have found that in an outpatient lupus population the severity of fatigue correlates strongly with health status as measured by the SF-36. There was no significant correlation with disease activity, measured by the SLEDAI or SLAM-R. Also, there was no correlation between fatigue and the SLICC/ACR damage index. The reporting of fatigue in SLE is therefore more reflective of the health status/QOL dimension of disease than disease activity or damage.

Fatigue severity correlated strongly with all domains of the SF-36. In addition, all the values of the SF-36 in SLE were lower than the reported normal values for a healthy female population. This suggests that there is a relation between poor QOL and the degree of fatigue reported that confirms our previous findings using the MOS SF-20.6 In addition, we have found that fatigue severity correlates with the tender point count and previously we have noted a correlation with higher scores on a depression inventory.6One potential explanation for this observation is that QOL and depression represent self report scales, and tenderness is partly dependent on the patient’s own self reporting. In contrast, disease activity and damage scales rely on the objective assessment of a trained physician. Therefore all the “patient centred” scales may be expected to closely correlate with a self reported scale of fatigue. It has been noted in studies of pain in RA that depression correlated well with self reported pain but not with observer rated pain behaviours.14 Certain pain behaviours did correlate well with disease activity.14 Objective study of fatigue associated behaviours has not been undertaken, but may be necessary to discover if our findings have been confounded by the self report nature of the questionnaires.

The correlation between the SLAM-R and SLEDAI is lower than previously reported.15 This initial study was performed by members of an international study group using “paper patients” over a broad range of disease activity. The lower correlation in our study may more closely reflect the correlation to be expected in a general clinic situation within a group of patients with a generally lower range of disease activity. We cannot exclude the possibility that there may be variation in the degree of fatigue that may occur during a major flare of disease. Studying patients over time would permit this question to be investigated and also enable assessment of the level of fatigue as a function of disease activity in individual patients. With regard to the SLAM-R, the modest correlation with fatigue severity was lost when the score for fatigue was omitted. Although each element of the SLAM-R demands attribution to active SLE,7 the scoring of fatigue and its attribution to active disease does, by necessity, require a degree of interpretation and clinical judgment. The inclusion of such subjective data in an activity score may therefore increase the risk of rater variability.8

A study such as this cannot discover the aetiology of fatigue in SLE. Fatigue may be a cause or consequence of a poor perception of health status. Alternatively, fatigue and perceived QOL/health status may be closely associated with other key psychosocial factors not assessed by this study. It is also possible that fatigue may reflect more subtle changes in CNS structure and physiology that cannot be assessed by activity and damage instruments currently used. Tests of neurocognitive function and/or sleep physiology may allow you to further assess CNS function in these patients. They may also provide objective assessment of some fatigue related behaviours that would in part elucidate the potential confounders described earlier.

Therefore, in an outpatient SLE population we have found that self reported fatigue severity has a strong negative correlation with all domains of the SF-36. There was no correlation with disease activity or organ damage. It would seem that in patients with SLE, factors associated with QOL/health status dimension of disease have a greater influence on the severity of fatigue than the degree of disease activity.

Acknowledgments

Funding: Dr I N Bruce is in receipt of the Geoffrey Carr Lupus Fellowship from the Ontario Lupus Association. This study was also supported in part by a grant from the Arthritis Society of Canada.

References

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