rss
Ann Rheum Dis 57:749 doi:10.1136/ard.57.12.749
  • Correspondence

Parotid lipomatosis in HIV positive patients: a new clinical disorder associated with protease inhibitors

  1. ALEJANDRO OLIVÉ
  1. Rheumatology Section
  2. Maxillofacial Surgery Service
  3. Pharmacology Service
  4. HIV Unit, Internal Medicine Service, Hospital Universitari “Germans Trias i Pujol”, Spain
  5. Pathology Service, Hospital Universitari Valle Hebrón, Spain
  1. Dr Olivé, Rheumatology Section, Hospital Universitari Germans Trias i Pujol, C Canyet sn Badalona 08916, Spain.
  1. AGUSTÍ SALAVERT
  1. Rheumatology Section
  2. Maxillofacial Surgery Service
  3. Pharmacology Service
  4. HIV Unit, Internal Medicine Service, Hospital Universitari “Germans Trias i Pujol”, Spain
  5. Pathology Service, Hospital Universitari Valle Hebrón, Spain
  1. Dr Olivé, Rheumatology Section, Hospital Universitari Germans Trias i Pujol, C Canyet sn Badalona 08916, Spain.
  1. MARCELA MANRÍQUEZ
  1. Rheumatology Section
  2. Maxillofacial Surgery Service
  3. Pharmacology Service
  4. HIV Unit, Internal Medicine Service, Hospital Universitari “Germans Trias i Pujol”, Spain
  5. Pathology Service, Hospital Universitari Valle Hebrón, Spain
  1. Dr Olivé, Rheumatology Section, Hospital Universitari Germans Trias i Pujol, C Canyet sn Badalona 08916, Spain.
  1. BONAVENTURA CLOTET
  1. Rheumatology Section
  2. Maxillofacial Surgery Service
  3. Pharmacology Service
  4. HIV Unit, Internal Medicine Service, Hospital Universitari “Germans Trias i Pujol”, Spain
  5. Pathology Service, Hospital Universitari Valle Hebrón, Spain
  1. Dr Olivé, Rheumatology Section, Hospital Universitari Germans Trias i Pujol, C Canyet sn Badalona 08916, Spain.
  1. AUGUST MORAGAS
  1. Rheumatology Section
  2. Maxillofacial Surgery Service
  3. Pharmacology Service
  4. HIV Unit, Internal Medicine Service, Hospital Universitari “Germans Trias i Pujol”, Spain
  5. Pathology Service, Hospital Universitari Valle Hebrón, Spain
  1. Dr Olivé, Rheumatology Section, Hospital Universitari Germans Trias i Pujol, C Canyet sn Badalona 08916, Spain.

    Protease inhibitors (PI) are a major advance in the treatment of HIV-1 infection. However, side effects of these drugs occur frequently.1 Abnormal fat accumulation in patients infected with HIV-1 has been described after starting treatment with PI.2 There might be several clinical disorders associated with fat deposition, namely increasing abdominal girth, abnormal dorsal cervical fat (“buffalo hump”), and hypertrophy of the breast.2-4 We report two cases of parotid fatty deposition associated with with retroviral treatment.

    case 1 A 54 year old heterosexual man with asymptomatic HIV infection of seven years duration was referred with a two year history of painless growing bilateral parotid swelling. He complained of dry mouth but not dry eyes. In June 1995 he was taking zidovudine (1200 mg twice daily). From January 1996 he …