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No endotoxin detected in plasma of patients with ankylosing spondylitis
  1. O MÄKI-IKOLA,
  2. J MERTSOLA,
  3. K GRANFORS
  1. P KUUSELA
  1. K LEHTINEN,
  2. R VON ESSEN
  1. H SAXEN
  1. National Public Health Institute, Turku, Finland
  2. The Haartman Institute, Department of Bacteriology and Immunology, University of Helsinki, Helsinki, Finland
  3. Rheumatism Foundation Hospital, Heinola, Finland
  4. Children’s Hospital, University of Helsinki, Helsinki, Finland
  1. Dr O Mäki-Ikola, National Public Health Institute, Department in Turku, Kiinamyllynkatu 13, FIN-20520 Turku, Finland.

https://doi.org/10.1136/ard.56.4.279

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    Endotoxin has long been known to be an important virulence factor for Gram negative bacteria. It is chemically classified as lipopolysaccharide (LPS) and it is one of the major constituents of the outer membrane of Gram negative bacteria. This molecule is also known to be responsible for many injurious effects of Gram negative bacterial infections and thus is clinically important.1

    The pathogenesis of ankylosing spondylitis (AS) is still unknown. A microbial aetiology has been suggested, as increased faecal carriage of Klebsiella spp, as well as increased antibody values, particularily against the LPS part of K pneumoniaehave been reported in AS patients.2 ,3 Furthermore, Wagener et al 4 have reported that the plasma endotoxin concentrations were increased in …

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