rss
Ann Rheum Dis 1997;56:596-600 doi:10.1136/ard.56.10.596
  • Extended reports

Pulmonary function tests and high resolution computed tomography of the lungs in patients with rheumatoid arthritis

  1. Bernard Corteta,
  2. Thierry Perezb,
  3. Nicolas Rouxa,
  4. René-Marc Flipoa,
  5. Bernard Duquesnoya,
  6. Bernard Delcambrea,
  7. Martine Rémy-Jardinc
  1. aDepartment of Rheumatology, CHRU Lille, Hôpital R Salengro, Lille, France , bDepartments of Pneumology , cand Radiology , dCHRU Lille, Hôpital Calmette, Lille, France
  1. Dr B Cortet, Department of Rheumatology, CHRU Lille, Hôpital R Salengro, 2 Avenue Oscar Lambret, 59037, Lille Cedex, France.
  • Accepted 30 June 1997

Abstract

OBJECTIVE To compare the results of pulmonary function tests (PFTs) and high resolution computed tomography (HRCT) of the lungs in rheumatoid arthritis (RA) patients.

METHODS Sixty eight patients (54 women, 14 men) fulfilling the revised criteria for RA were consecutively included in a transversal prospective study. Their mean age was 58.8 years (range: 35–82) and the mean duration of the disease was 12 years (range: 5–16). Rheumatoid factor was positive in 52 patients (76.5%). Fifty two patients (76.5%) were lifelong non-smokers. Detailed medical and drug histories were obtained. PFTs comprised spirometry and gas transfer measurements. Results for PFTs were expressed as percentage of predicted values for each individual adjusted for age, sex, and height. HRCT was undertaken with a Siemens Somatom Plus.

RESULTS A significant decrease of FEV1/FVC, FEF25%, FEF50%, FEF75%, FEF25–75%, and TLCO was observed (p<0.05) and 13.2% of the patients had a small airways involvement defined by a decrease of FEF25–75% below 1.64 SD. The most frequent HRCT findings were: bronchiectasis (30.5%), pulmonary nodules (28%), and air trapping (25%). The patients with small airways involvement had a high frequency of recurrent bronchitis (75% v 34%, p=0.05) and bronchiectasis (71% v 23%, p=0.019). The patients with bronchiectasis were characterised by low values of FEV1, FVC, FEF25–75%, and TLCO (p<0.01), a high prevalence of small airways involvement (29% v 5%, p=0.019), and a low prevalence of HLA DQA1 *0501 allele (14% v 33%, p<0.05).

CONCLUSION This study suggests a significant association between small airways involvement on PFTs and bronchiectasis on HRCT in unselected RA patients.

Footnotes

    This Article

    1. Abstract
    2. Full text
    3. PDF

    Responses

    1. Submit a response
    2. No responses published

    Register for free content

    The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.

    Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.