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Ann Rheum Dis 1997;56:41-44 doi:10.1136/ard.56.1.41
  • Extended reports

ICAM-1, E-selectin, and TNF α expression in labial salivary glands of patients with rheumatoid vasculitis

  1. René Marc Flipoa,
  2. Thierry Cardona,
  3. Marie Christine Copinb,
  4. Marie Vandecandelaerea,
  5. Bernard Duquesnoya,
  6. Anne Janinb
  1. aHôpital Calmette, Lille, France: Department of Rheumatology , bDepartment of Pathology C
  1. Pr René-Marc Flipo, Department of Rheumatology, Hôpital Roger Salengro, CHRU, 59037 Lille cedex, France.
  • Accepted 11 October 1996

Abstract

OBJECTIVE To assess the expression of ICAM1, VCAM1, E-selectin, CD44, and TNF α in labial salivary glands of patients with rheumatoid vasculitis.

METHODS Labial salivary glands from six patients with rheumatoid vasculitis before and after treatment, six aged matched rheumatoid arthritis patients without clinical evidence of rheumatoid vasculitis, 10 patients with primary Sjögren syndrome, 10 patients with rheumatoid arthritis and proven secondary Sjögren syndrome, and six controls were tested with specific antibodies.

RESULTS ICAM1, E-selectin, and TNF α were significantly expressed in endothelial cells and perivascular cellular infiltrate only in rheumatoid vasculitis before treatment.

CONCLUSIONS The expression of ICAM1, E-selectin, and TNF α allows an assessment of the activity of the vasculitic process in rheumatoid vasculitis. Labial salivary gland biopsy findings in patients with rheumatoid arthritis and visceral vasculitis without purpura or neuropathy (that is, mesenteric, coronary, or cerebral vasculitis) would be of interest and are examples where labial salivary gland tissue is more accessible than the affected tissue.

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