Ann Rheum Dis 55:486-488 doi:10.1136/ard.55.7.486
  • Research Article

Hydroxychloroquine and lupus pregnancy: review of a series of 36 cases.

  1. N M Buchanan,
  2. E Toubi,
  3. M A Khamashta,
  4. F Lima,
  5. S Kerslake,
  6. G R Hughes
  1. Lupus Pregnancy Clinic, St Thomas' Hospital, London, United Kingdom.


      OBJECTIVE: To study maternal and fetal outcome of pregnancy in patients with lupus who were exposed to hydroxychloroquine (HCQ). METHODS: The case records of women (n = 33) exposed to HCQ during their pregnancies (n = 36) and of 53 control patients from a single lupus pregnancy centre were reviewed to determine lupus activity, obstetric experience, and infant outcome. RESULTS: HCQ was not apparently teratogenic. Lupus activity and obstetric outcome in the two groups were similar. CONCLUSION: HCQ continuation is probably safe during pregnancy in patients with lupus, but there is no obvious advantage in commencing treatment.