Article Text

PDF

Increased urinary nitrate excretion in rats with adjuvant arthritis.
  1. D O Stichtenoth,
  2. F M Gutzki,
  3. D Tsikas,
  4. N Selve,
  5. S M Bode-Böger,
  6. R H Böger,
  7. J C Frölich
  1. Department of Clinical Pharmacology, Hannover Medical School, Germany.

    Abstract

    OBJECTIVES--In rats with adjuvant arthritis measurements were taken of the urinary excretion of nitrate, reflecting endogenous nitric oxide (NO) formation, and cyclic guanosine monophosphate (cGMP). METHODS--Urinary nitrate was determined by gas chromatography, cGMP by radioimmunoassay. RESULTS--A significant (p < 0.001), more than three fold increase of urinary nitrate excretion was found in rats 20 days after induction of adjuvant arthritis compared with non-arthritic rats. There was no significant difference in urinary cGMP excretion between arthritic rats and control animals. CONCLUSION--The data suggest that the dramatic increase of urinary nitrate excretion is due to increase of NO synthesis by the inducible form of NO synthase.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.