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Antibodies to endothelial cells in Behçet's disease: cell-binding heterogeneity and association with clinical activity.
  1. R Cervera,
  2. M Navarro,
  3. A López-Soto,
  4. M C Cid,
  5. J Font,
  6. J Esparza,
  7. J C Reverter,
  8. J Monteagudo,
  9. M Ingelmo,
  10. A Urbano-Márquez
  1. Department of Internal Medicine, Hospital Clinic, Barcelona, Spain.

    Abstract

    OBJECTIVES--To investigate the prevalence and characteristics of antibodies to endothelial cells (aEC) from large vessel and from microvasculature in a group of patients with Behçet's disease (BD) to determine the relationship of these antibodies with clinical and laboratory features of the disease. METHODS--Thirty patients with BD were prospectively and consecutively studied. The aEC were determined by enzyme-linked immunosorbent assay (ELISA) using endothelial cells derived from human umbilical vein (large vessel) as well as from retroperitoneal adipose tissue (microvasculature). RESULTS--Fifteen patients (50%) had aEC, either directed to large vessel [8(26%) patients] or microvascular [13(43%) patients] endothelial cells. The percentage of active patients was significantly higher in the aEC-positive group [12(80%) patients] compared with the aEC-negative group [5(33%) patients] (p < 0.05). CONCLUSIONS--Patients with BD have a high prevalence of aEC when microvascular endothelial cells are used in the assay. These antibodies seem to be a marker of disease activity in this condition, previously considered as negative for autoantibodies.

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