Article Text


Systemic lupus erythematosus induced by isoniazid.
  1. M Salazar-Páramo,
  2. R L Rubin,
  3. I García-De La Torre
  1. Department of Immunology and Rheumatology, Hospital General de Occidente de la S.S., Zapopan, Jalisco, Mexico.


    The case is described of a 73 year old man who presented with a lupus-like syndrome related to treatment with isoniazid and had IgG antinuclear antibodies against the nucleo-histone complex (H2A-H2B)-DNA. After a short course of treatment with prednisone and discontinuation of isoniazid the patient's lupus symptoms resolved and a gradual decrease in antibodies to (H2A-H2B)-DNA occurred. This case suggests that isoniazid is capable of inducing an autoantibody specificity associated with drug related lupus.

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