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Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis.
  1. M L Selley,
  2. D J Bourne,
  3. M R Bartlett,
  4. K E Tymms,
  5. A S Brook,
  6. A M Duffield,
  7. N G Ardlie
  1. Division of Clinical Sciences, John Curtin School of Medical Research, Australian National University, Royal Canberra Hospital, Garran, ACT.

    Abstract

    (E)-4-Hydroxy-2-nonenal (HNE), a cytotoxic propagation product of lipid peroxidation, is present in the synovial fluid (0.54 (0.19) mumol/l; mean (SE), n = 9) and plasma (0.34 (0.09) mumol/l, n = 9) of patients with rheumatoid arthritis. This compound was also found in the synovial fluid (0.24 (0.19) mumol/l, n = 9) and plasma (0.09 (0.03) mumol/l, n = 9) of patients with osteoarthritis. The concentration of HNE in the plasma of patients with rheumatoid arthritis was significantly greater than in patients with osteoarthritis.

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