Article Text

PDF

Decreased fibrinolytic activity in juvenile chronic arthritis.
  1. L Mussoni,
  2. G Pintucci,
  3. G Romano,
  4. F De Benedetti,
  5. M Massa,
  6. A Martini
  1. Istituto di Ricerche, Farmacologiche Mario Negri, Milan, Italy.

    Abstract

    The basal fibrinolytic activity in 17 children with active juvenile chronic arthritis (JCA) was investigated. It was found that patients with JCA, and particularly those with the systemic form, show decreased plasma fibrinolytic activity and a marked increase in plasminogen activator inhibitor. Additionally, it was found that patients with systemic JCA, but not those with the polyarticular or pauciarticular form, have increased circulating levels of tissue-type plasminogen activator, and endothelial cell protein, suggesting possible endothelial cell participation in systemic JCA.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.