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5-fluorouracil in the treatment of scleroderma: a randomised, double blind, placebo controlled international collaborative study.
  1. J A Casas,
  2. P A Saway,
  3. I Villarreal,
  4. C Nolte,
  5. B L Menajovsky,
  6. E E Escudero,
  7. W D Blackburn,
  8. G S Alarcón,
  9. C P Subauste
  1. Department of Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.

    Abstract

    A six month controlled study of 5-fluorouracil in the treatment of scleroderma showed a modest benefit in skin scores, Raynaud's phenomenon, and patients' global assessment. Visceral organ and hand function were unaffected. Mild to moderate toxicity was common in the 5-fluorouracil treated patients but usually responded to dose reduction. Two patients receiving 5-fluorouracil died from causes seemingly unrelated to treatment. Significant clinical improvement in scleroderma was not noted in the first six months of treatment with 5-fluorouracil.

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