Article Text

PDF

Is poor pregnancy outcome a risk factor in rheumatoid arthritis?
  1. T D Spector,
  2. A J Silman
  1. Department of Rheumatology, St Bartholomew's Hospital, London.

    Abstract

    Previous work has suggested that prior poor reproductive outcome may be a risk factor in rheumatoid arthritis (RA). A case-control study of 195 women with RA and 462 control women from two different sources is presented here. No increase in rates of spontaneous abortion was seen in the women with RA; indeed a protective effect was seen with an age adjusted odds ratio of 0.6 (95% confidence interval (CI) 0.4 to 0.9). A non-significant increase in stillbirth rates was seen in women with RA, producing an age adjusted odds ratio of 1.5 (95% CI 0.7 to 3.4). No differences in rates of induced abortion were seen. Thus although hormonal and gynaecological factors are undoubtedly important in the aetiology of RA, it was not possible to confirm that prior poor reproductive outcome is a risk factor in RA.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.