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HLA types in patients with rheumatoid arthritis developing leucopenia after both gold and sulphasalazine treatment.
  1. H Bliddal,
  2. B Eiberg,
  3. P Helin,
  4. A Svejgaard
  1. Department of Rheumatology, Bispebjerg Hospital, Copenhagen, Denmark.


    HLA types, especially HLA-DR3, are associated with the development of toxic reactions in patients with rheumatoid arthritis after treatment with gold or D-penicillamine. In this study, after treatment with sulphasalazine, leucopenia was observed in three patients, who all had a history of leucopenia after previous gold treatment. The HLA types of these patients did not include HLA-DR3; the two patients developing mild leucopenia had HLA-DR2 and the one developing agranulocytosis had HLA-DR4.

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